16 Night Panama Canal Cruise

Cradled by mountains and lapped by the cerulean waters of the Pacific, Mazatlán is one of the most interesting resort towns on Mexico’s wild western coast. If you’re planning a cruise to Mazatlán, you’re in for a real treat. You’ll find it all here — stately plazas and shaded streets lined with restored landmarks in the city’s Centro Historico. Beautiful white-sand beaches dotted with lively cafes, bars and plenty of space to sunbathe. And endless ways to dive into the region’s unique history, which is filled with Spanish conquistadors, buccaneer battles, and Gold Rush-era prospectors.

Puerto Quetzal is the ideal starting point to discover some of Guatemala's most iconic attractions. After a short ride outside of this port city, roam the Spanish Colonial streets of Antigua, a UNESCO World Heritage Site, with the colossal Volcan de Agua in the background. Cruise to Puerto Quetzal and learn how to weave using the back-strap loom technique or how to grind coffee by hand from the Maya women of San Antonio Aguascalientes. Then, reach Guatemela's highlands, and get happily lost in the town of Panajachel, with its pastel-colored houses that face idyllic Lake Atitlan.

Situated on the long Nicoya Peninsula, Puntarenas is a great jumping-off point for the eco-adventures that have made Costa Rica famous. Trek lush rainforests in San Luis Park. Discover tropical flora and fauna in Pos Volcano National Park, and shower under Costa Rica's tallest waterfall at Pura Vida Gardens and Waterfalls. Looking for oceanside adventure? Take the short drive from Puntarenas to the Nicoya Peninsula, where there's a wide array of beaches — relax on family-friendly Playa Guiones, or check out dramatic Playa Ostional, with its volcanic black sands and vibrant sea turtle population. Puntarenas cruises give you access to Playa Tamarindo, where you can find some of the best surf and food in the country.

Home to the Panama Canal's Atlantic Ocean entryway, Colón is the second-largest city in Panama. Start your adventure at the Gatun locks, where you can watch ships being raised by water lifts to the higher elevation of the canal. Then, visit the Portobelo Natural Park and take in the beauty of its 16th century forts. Or head to the beach at Playa Maria Chiquita for clear Caribbean Sea waters and white sands. Cruise to Colón, Panama and check out Portobelo National Park, where you can see 17th-century Fort San Lorenzo or go bird-watching along the Achiote Trail in San Lorenzo Protected Forest. Or take the one-hour trek to Panama City, the Caribbean's urban heartbeat.

Cartagena de Indias boasts romantic colonial architecture and a Caribbean coast glittering in shades of bright white and aquamarine. Saunter through the leafy Plaza de Bolivar, photographing multicolored streets like Calle Segunda de Badillo. Cruise to Cartagena to dance to the beat of merengue, salsa and Colombia's very own cumbia at places like Bazurto Social Club. Discover Proclamation Square, where the town people gathered in 1811 in support of the declaration of independence from Spain, and walk the 16th-century fortifications of Castillo San Felipe de Barajas. Enjoy Cartagena's natural grandeur on its many beaches, like Bocagrande, Playa Blanca and placid Rosario Islands National Park, just 45 minutes away from the city.